I need a solution on – Describe the symptoms and how this condition manifests.-Describe the symptoms and how this condition manifests.

OverviewOne of the most vital reasons for studying biochemistry is for the purpose of biomedical research. Practically all human conditions or disorders can be described on a biochemical level, and almost all medical research toward finding a way to ease those conditions involves biochemical research. Scientists must understand biochemical pathways and biochemical interactions among molecules to produce most medications. It’s necessary for the production of the medicine to combat whatever the condition is and also prevent negative interactions in other biochemical pathways.
The text covers many medical conditions and disorders. Select one of them that’s of special interest to you and find a peer-reviewed academic research paper where the scientists used one of the biochemical research techniques overviewed in this course. Describe the disease, disorder, or condition; its biochemical origins; the biochemical techniques used to study this disorder in the academic article; and how this technique was used to reach the conclusions about the disease, disorder, or condition you chose.
InstructionsChoose one of the diseases, disorders, or conditions that have been mentioned in the textbook for this course.
Once you choose a disease, disorder, or condition, find a relatively recent research article (published no earlier than 2000) researching some aspect of your chosen condition.
The article must come from a peer-reviewed academic journal with an impact factor rating no lower than 2.The article must discuss one of the biochemical techniques mentioned in this course, most of which are covered in sections 2.4 and 7.1.Possible focus topics include:
Understanding the mechanism of a disease or disorder, such as through fluorescence labeling, looking at products on an SDS-PAGE, or various analyses: Researchers use many techniques to explain which proteins may be involved in the manifestation of a disease or disorder and can be very creative with the techniques used in this process.A possible pharmaceutical to combat your chosen disorder or to function as a treatment: Many techniques are used in the process of discovering, synthesizing, and testing various possible medications. These compounds are usually some sort of agonist, antagonist, or inhibitor.ProcedureOnce you have an appropriate article that fits all the criteria, begin to write your paper. Make sure to answer all of the following questions and meet all of the following criteria.
Describe the disease, disorder, or condition.Clearly introduce the disease, disorder, or condition you chose.Describe the symptoms and how this condition manifests.If it’s a genetic disorder, is it heritable? If not, where does it come from?If it’s a disease, how do people contract it?If it’s a condition, what causes it? Is it chronic or acute?Describe any treatments. Don’t just list medications—explain what these medications do. For other types of dietary changes or therapies, explain why they help.If it’s a disease, what is the cure? If there’s no cure, what are the common treatments?If it’s a condition or disorder, what are the common treatment options?Describe what issues researchers are still facing for your chosen condition.If there’s no cure, why not?If there are issues with the treatment options (such as side effects), what are they?If the metabolic or signaling pathways affected aren’t fully understood, what are researchers currently focusing on in hopes of discovering something important?If there’s hope that a new technique will be very good for treatment (e.g. CRISPR-Cas9), are there any issues researchers are still attempting to overcome before it can be fully successful?Is there a particular enzyme, protein, RNA, or segment of DNA that researchers don’t understand and need more information about? If so, what’s difficult about obtaining important information (such as structural information) about the molecule?Describe the biochemical basis for the disease, disorder, or condition.Describe the normal behavior of the biochemical pathway or structure that’s affected by your chosen condition (that is, in individuals without the disease, disorder, or condition).If fatty acid metabolism is affected, describe fatty acid metabolism in detail.If glucose metabolism is affected, describe the section of sugar metabolism affected in detail.If there’s a particular protein affected by the condition, make sure to explain that protein’s normal function.Describe how the disease, disorder, or condition affects this biochemical pathway or physiological structure.How does it result in physical symptoms?Which biochemical macromolecules are affected?If it’s a gene mutation, which gene? How is it mutated? What’s the result of this mutation—loss of protein function? Lowered rate? Or a different type of reaction entirely?Is there a homeostatic imbalance? What is it? Which reactions occur at a different rate from before? Which chemical equilibria are affected?If it’s a structure, what about it is different? What biochemical changes result in the structural differences?Describe the biochemical technique used in the academic research paper.Clearly state which technique you’re focusing on from the academic paper.Describe the general theory behind how this technique works. Describe any principles necessary for understanding how the technique works. (For instance, with SDS-PAGE, the gaps between polyacrylamides are what impede proteins based on their different molecular weights and sizes.)Describe the steps involved in using the technique. Explain how scientists would physically go about setting up an experiment.What materials do they need?How must their sample be prepared?How much do they need?What sort of controls are used? If none are used, why not?Explain the type of data obtained from the technique and how it’s interpreted. (For example, in SDS-PAGE, the final product is a gel with bands on it. The bands must then be compared to a molecular ladder of known molecular weight that was run side-by-side. The weight of the ladder bands can be graphed versus the distance moved, and the distance of the sample can be compared to the graph to obtain a molecular weight.)Describe the type of scenarios in which scientists would choose to use the technique. (For example, SDS-PAGE is used to obtain molecular weight during processes such as protein purification to check for purity, checking for molecular cleavage, or for other molecular alterations that involve changes to molecular weight.)Describe the limitations or drawbacks of the technique and how they may be compensated for. (For example, with SDS-PAGE, some proteins with strong charges can outweigh the effect of SDS and can cause a protein to “run heavy,” making the technique no longer useful for finding out the molecular weight of such a protein. However, knowing the amino acid sequence of a protein can help know the molecular weight of the protein without using SDS-PAGE.)Describe the use of the biochemical technique to research the condition, disease, or disorder.Summarize the overall hypothesis of the chosen academic paper. Make sure not to quote directly. Instead, use your own words to describe what the authors are proving or disproving with their experiment.Describe what aspect of your chosen condition the authors are focusing on in their academic paper.How does their research relate to your chosen condition?Is it a direct connection, or does the research focus on an affected protein in a metabolic or signaling pathway affected by the condition?Describe how the authors used the technique in their academic paper.Summarize the materials and methods used for this technique (do not quote directly).Describe any substrates and summarize in a sentence or two how the samples are prepared.Explain any controls that are run or baselines formed.Describe the data obtained using the technique.Describe the units of the data collected and give an example of one of the data points, if possible.If there’s a figure, describe it in detail and how the data was used to obtain it.Describe the axes, what the points on the graph or figure may represent, and then how this data would be interpreted.Explain why the figure helps explain the data obtained from the technique better than a table or other method. If a table is used instead, explain why the table is sufficient for explaining what the data shows.Summarize the conclusions the authors of the paper reached about their data using the technique. Don’t quote directly, but summarize what they say the technique showed them or what it was used to conclude.Offer your opinion: Do you think the authors did a fair job of interpreting the results of their data using this technique? Make sure not to use “I” statements and instead focus on facts from the paper and your knowledge of the technique and its limitations. If you agree with the assessment, defend the position by mentioning the shortcomings of the technique and how the authors addressed them.Describe the conclusions the academic paper reached.Summarize the conclusions that the authors reach in the entire academic paper. Again, make sure not to quote directly but rather to summarize in your own words.Summarize what the authors say about their conclusions in relation to your chosen condition. How does it affect the study of the condition? Does it answer any important questions that had existed about the condition? If they don’t mention the condition directly, summarize how it affects the research on the condition yourself based on your knowledge of the current understanding of the condition.Summarize what the authors say about future directions or possible applications for their research.What do they say their research will impact?Could it lead to possible cures or treatments?Does it expand the knowledge of the signaling or metabolic pathways in this condition?Offer your opinion: Do you feel the conclusions of the authors were fair and relate properly to their obtained data? Again, defend your position based on your knowledge of the chosen condition as well as your overall biochemical knowledge from this course.Use proper formatting.Make sure to use correct grammar, citations, and to include a bibliography.
The project should be no longer than five pages.Include a reference page at the end of the paper with citations to all scientific articles, offered in proper APA formatting.Format the paper in 12-point Times New Roman font.Use proper grammar and spelling throughout the paper. Avoid using first person (“I think,” “I believe”) and instead stick to general statements (“Although the authors of the paper conclude that their hypothesis is correct, the data shows that . . . ”).
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